Drug Reverses 'Accelerated Aging' in Human Cells

The drug rapamycin has been found to reverse the effects of Hutchinson-Gilford progeria syndrome, a fatal genetic disease that resembles rapid aging, in cells taken from patients with the disease. Rapamycin, an immunosuppressant drug used to prevent rejection of transplanted organs, has already been shown to extend life span in healthy mice. Researchers hope the findings will provide new insight into treating progeria as well as other age-related diseases.

Skin cells from patients with progeria show a slew of defects: deformities in their membranes, decreased growth, and early death. Kan Cao, an associate professor of cell biology and molecular genetics at the University of Maryland, and her colleagues found that rapamycin could reverse these defects by enhancing the cells' ability to degrade the protein progerin, which accumulates in abnormal amounts in progeria patients. The study was published today in the journal Science Translational Medicine.

It's not yet clear whether the drug will have similar effects on animals or patients. But progeria researchers are planning a clinical trial of rapamycin. No treatments currently exist for the disease, which is typically fatal by age 12. Children with progeria have health issues typically associated with old age, including balding, hardened skin, pain in joints, hip dislocations, and heart disease.

Researchers say the findings could be relevant beyond this rare genetic disease. Although accumulation of progerin is associated with progeria, the protein also accumulates in small amounts in normal cells, and may be partially responsible for the aging process.

Some age-related diseases, such as Parkinson's and Alzheimer's, also result in defects in the cells' "trash-removal" system, says Dimitri Krainc, associate professor of neurology at Harvard Medical School and one of the authors of the paper. In fact, previous research has shown that the failure of cellular maintenance is a key component of aging. "With normal aging ... you start accumulating by-products of normal cell functions," explains Krainc. Rapamycin may be able to help clean up other toxic proteins as well, though this study only looked at its effects on progerin.

"I would hope that the study increases the search for molecules to replace rapamycin," which don't have the immunosuppressant side effects, says David Sinclair, director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Such alternatives could be a major step forward in the fight against aging, says Sinclair, who was not involved in the current study.

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Tea Party Finds Power Leads to Policy Splits

Instead, the bill, which would provide vouchers to poor families who want better schools for their children, has sparked what one Tea Party activist called a ?fight within the family.?

Many Tea Party groups oppose the bill because it does not establish universal school choice, and call it a bailout of failing schools. They accuse those who support it ? who are backed by a powerful Washington group that has helped cultivate the Tea Party ? of selling out to the kind of politics-as-usual approach that the movement was founded to oppose. Supporters say those opponents do not understand that compromise is part of politics.

The disagreement resonates beyond the local particulars. It offers a microcosm of the Tea Party?s struggle as it tries to turn the potency it showed in the midterm elections into influence in legislative battles and the 2012 presidential campaign. Having been brought together primarily by what they oppose, Tea Party groups have had difficulty agreeing on what they stand for. Just saying ?Tea Party? strikes fear in many Republicans in Washington and state capitols. But in practice, the Tea Party is often fractious and undefined.

In Tennessee, a split between Tea Party groups forced legislators to scale back antiterrorism legislation that toughened state penalties for people who support terrorist groups. While the social conservatives in the movement supported it, those on the libertarian end of the Tea Party spectrum argued that the bill, originally aimed at Islamic groups, was a government intrusion on personal liberties.

In Indiana, Tea Party groups had vowed to unite behind a challenger to run against Senator Richard G. Lugar in the Republican primary in 2012, but soon fell to disagreement, with some groups refusing to attend a planned nominating convention.

And earlier this month, some Tea Party groups objected when Amy Kremer, the leader of the Tea Party Express, a group founded by longtime Republican consultants, told an interviewer that Tea Party supporters would fall in line behind whoever became the Republican nominee for president.

?I think people see this movement that became enormous and powerful and they are trying to harness it,? said Jennifer Stefano, one of the Pennsylvania Tea Party members who has opposed the school choice bill. ?And everyone who asks my advice on how to do this, I tell them not to try, because it?s not possible.?

Pennsylvania, a perennial swing state, was an early breeding ground for the Tea Party movement. In April 2009, Anastasia Przybylski, a mother in Bucks County, was inspired to hold a ?roast the pork? protest against the federal stimulus bill at the site where George Washington rallied his troops before crossing the Delaware to attack British forces. Ms. Przybylski and her co-organizers sent the information about the event to FreedomWorks, the Washington powerhouse led by Dick Armey, the former House Republican leader, which was trying to publicize Tea Party events across the country. Soon, FreedomWorks had enough contacts in the state that it held training sessions for Pennsylvania Tea Party activists.

FreedomWorks encouraged its trainees to learn from the teachings of Saul Alinsky, the father of modern community organizing and a hero of the left. They advocated a high pressure, win-at-any-cost approach, advising activists to use ridicule, agitate and disrupt to get what they wanted.

After the midterm elections, the group hired Ms. Przybylski and Ana Puig, another activist, who called their group the Kitchen Table Patriots, to lobby for a school choice bill here.

FreedomWorks is pushing anti-union legislation in several states, and saw the school choice legislation as part of that larger battle.

The bill would give vouchers to students in failing schools who are poor enough to qualify for the federal free lunch program. The amount would vary according to how much money the state contributes to each district and would be expanded to a limited number of additional students in the second and third years of the program. It would cost an estimated $50 million in the first year, $100 million in the second and $1 billion in the third.

FreedomWorks hoped that having Ms. Puig and Ms. Przybylski?s support would give the bill grass-roots credibility.

But many Tea Party groups objected, saying the bill violates the principles they have fought for, in particular, the libertarian tenet that the government cannot take property from one person against his will for the benefit of someone else. The bill, they argue, amounts to another government entitlement program.

?It creates class warfare,? said Sharon Cherubin, an activist in Lancaster County who home schools her children. ?Is it fair that John Doe?s family earns a penny over poverty level and his parents have to sacrifice and work four jobs while the next guy gets a free ride??

This article has been revised to reflect the following correction:

Correction: June 28, 2011

A photo caption with an earlier version of this article misidentified the location of Anastasia Przybylski and Ana Puig. They were in Harrisburg, Pa., not Baltimore.

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Sprint doing everything it can to stop AT&T's T-Mobile acquisition

Sprint Nextel CEO Dan Hesse is still hard at work outlying tactics to stop AT&T's proposed takeover of T-Mobile USA. Hesse has already tripled the amount of time he's spending on government affairs, testifying before Congress and making regular trips to Washington. He's also courting top technology CEOs to come out against the deal and sway public opinion, working to get as many as 18 state regulators to scrutinize the purchase, and strategizing other tactics he's not ready to disclose.

Sprint is organizing industry opposition and recently filed a 377-page dissent with the Federal Communications Commission (FCC). The company's own engineers even made a point to show AT&T how to get more capacity from its wireless network so it wouldn't need to buy T-Mobile.

"Clearly, purely, we want to win and block the merger," Hesse told Bloomberg during an interview at the company's Overland Park, Kansas headquarters. "This one poses real risks."

Last week, AT&T declared that it was still on track to have its acquisition of T-Mobile approved by March 2012. AT&T General Counsel Wayne Watts said the company provided a second round of information requested by the Justice Department and that meetings with the FCC were also going as scheduled.

AT&T has reportedly promised to give Deutsche Telekom $6 billion in assets, services, and cash as a break-up fee if US regulators reject the deal. The $6 billion would include $3 billion of cash, about $2 billion worth of spectrum, and a roaming agreement valued at $1 billion.

Three months ago, AT&T announced that it had entered into a definitive agreement to acquire T-Mobile from Deutsche Telekom in a cash-and-stock transaction valued at approximately $39 billion. The acquisition of T-Mobile, the fourth largest carrier in the US, would enable AT&T, currently the second largest US mobile service, to leapfrog the leader of the US market, Verizon Wireless, a venture of Verizon Communications and Vodafone Group.

Furthermore, AT&T and Verizon Wireless would hold 79 percent of the US market if regulators approved the deal, leaving Sprint as an even weaker number three player in the US. Unsurprisingly, it is doing everything in its power to appeal the huge deal.

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Source: http://www.techspot.com/news/44460-sprint-doing-everything-it-can-to-stop-atts-t-mobile-acquisition.html

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Reports say that webOS could come to Samsung devices

I have to admit it ? I loved webOS. What I hated was Palm?s ludicrous failure in marketing an otherwise brilliant OS. Since the HP purchase I had pretty much given up hope of webOS amounting to anything in the mobile market share, but some news today could have things looking up.

SlashGear reports that HP has been in active licensing talks concerning webOS. In short, that means that we could see the super-slick operating system coming to devices other than the HP-manufactured TouchPad. If the rumors hold true, some of those devices could carry the Samsung name, adding to the Korean-born manufacturer?s mobile arsenal.

Outside of the Apple, Samsung arguably makes some of the most impressive mobile devices in the world. While the credit for the Sammy rumor is given only to ?three unnamed sources?, it?s a safe bet that Samsung is looking to branch itself out from simply being an Android manufacturer in the increasingly-crowded robot space.

We?ll have to wait and see, but this is one rumor that you can bet we?ll be keeping an eye on here at TNW Mobile.

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Source: http://thenextweb.com/mobile/2011/06/29/reports-say-that-webos-could-come-to-samsung-devices/

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Tea Party Finds Power Leads to Policy Splits

Instead, the bill, which would provide vouchers to poor families who want better schools for their children, has sparked what one Tea Party activist called a ?fight within the family.?

Many Tea Party groups oppose the bill because it does not establish universal school choice, and call it a bailout of failing schools. They accuse those who support it ? who are backed by a powerful Washington group that has helped cultivate the Tea Party ? of selling out to the kind of politics-as-usual approach that the movement was founded to oppose. Supporters say those opponents do not understand that compromise is part of politics.

The disagreement resonates beyond the local particulars. It offers a microcosm of the Tea Party?s struggle as it tries to turn the potency it showed in the midterm elections into influence in legislative battles and the 2012 presidential campaign. Having been brought together primarily by what they oppose, Tea Party groups have had difficulty agreeing on what they stand for. Just saying ?Tea Party? strikes fear in many Republicans in Washington and state capitols. But in practice, the Tea Party is often fractious and undefined.

In Tennessee, a split between Tea Party groups forced legislators to scale back antiterrorism legislation that toughened state penalties for people who support terrorist groups. While the social conservatives in the movement supported it, those on the libertarian end of the Tea Party spectrum argued that the bill, originally aimed at Islamic groups, was a government intrusion on personal liberties.

In Indiana, Tea Party groups had vowed to unite behind a challenger to run against Senator Richard G. Lugar in the Republican primary in 2012, but soon fell to disagreement, with some groups refusing to attend a planned nominating convention.

And earlier this month, some Tea Party groups objected when Amy Kremer, the leader of the Tea Party Express, a group founded by longtime Republican consultants, told an interviewer that Tea Party supporters would fall in line behind whoever became the Republican nominee for president.

?I think people see this movement that became enormous and powerful and they are trying to harness it,? said Jennifer Stefano, one of the Pennsylvania Tea Party members who has opposed the school choice bill. ?And everyone who asks my advice on how to do this, I tell them not to try, because it?s not possible.?

Pennsylvania, a perennial swing state, was an early breeding ground for the Tea Party movement. In April 2009, Anastasia Przybylski, a mother in Bucks County, was inspired to hold a ?roast the pork? protest against the federal stimulus bill at the site where George Washington rallied his troops before crossing the Delaware to attack British forces. Ms. Przybylski and her co-organizers sent the information about the event to FreedomWorks, the Washington powerhouse led by Dick Armey, the former House Republican leader, which was trying to publicize Tea Party events across the country. Soon, FreedomWorks had enough contacts in the state that it held training sessions for Pennsylvania Tea Party activists.

FreedomWorks encouraged its trainees to learn from the teachings of Saul Alinsky, the father of modern community organizing and a hero of the left. They advocated a high pressure, win-at-any-cost approach, advising activists to use ridicule, agitate and disrupt to get what they wanted.

After the midterm elections, the group hired Ms. Przybylski and Ana Puig, another activist, who called their group the Kitchen Table Patriots, to lobby for a school choice bill here.

FreedomWorks is pushing anti-union legislation in several states, and saw the school choice legislation as part of that larger battle.

The bill would give vouchers to students in failing schools who are poor enough to qualify for the federal free lunch program. The amount would vary according to how much money the state contributes to each district and would be expanded to a limited number of additional students in the second and third years of the program. It would cost an estimated $50 million in the first year, $100 million in the second and $1 billion in the third.

FreedomWorks hoped that having Ms. Puig and Ms. Przybylski?s support would give the bill grass-roots credibility.

But many Tea Party groups objected, saying the bill violates the principles they have fought for, in particular, the libertarian tenet that the government cannot take property from one person against his will for the benefit of someone else. The bill, they argue, amounts to another government entitlement program.

?It creates class warfare,? said Sharon Cherubin, an activist in Lancaster County who home schools her children. ?Is it fair that John Doe?s family earns a penny over poverty level and his parents have to sacrifice and work four jobs while the next guy gets a free ride??

This article has been revised to reflect the following correction:

Correction: June 28, 2011

A photo caption with an earlier version of this article misidentified the location of Anastasia Przybylski and Ana Puig. They were in Harrisburg, Pa., not Baltimore.

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Google takes aim at Facebook with Google

Google hasn't had much luck with its social networking efforts in the past, but the company is ready to give it another go with an ambitious project that brings together some good ideas from the reigning king of social networks with its own. The service, dubbed Google+, will initially be available only to a limited number of users as part of a "field trial."

The site bears a definite resemblance to Facebook, with streaming feeds where users can share and discuss status updates, photos and links. But Google hopes to differentiate itself by more closely mimicking the way we organize our friends in real life, which is why its new service is designed for sharing with small groups -- like colleagues, family members or close buddies -- instead of with all of a user's friends or the entire web.

It's worth noting that Facebook offers similar functionality within its revamped Groups feature, launched in October 2010 apparently with knowledge of Google's plans, but so far it doesn't seem to have taken off.

There are five basic components to Google+: Circles, Sparks, Hangouts, Instant Uploads and Huddle. The first is Google+'s method of managing friends, where you can create different circles of contacts and add people to them. When you add people to circles in Google+, they'll see that you've connected with them, but they won't see which circle you've put them in. When posting something, Google+ allows you to select which circles can see the content, and conversely when viewing your stream you can filter by circles to cut out the noise and focus on what you are interested in.

Sparks lets you subscribe to specific interest of yours -- "gaming" or "football", for example -- and then goes out and gathers relevant content from all over the web to give you a constantly updated feed.

Hangouts is perhaps the most interesting of the bunch and puts applications like Skype on notice. Basically it allows live video conversations with up to 10 friends at once. You can click on the Hangout button and notify members of a certain group that you are available and ready to talk, creating spontaneous meetings with friends or colleagues. The main video box shows the person who's speaking the loudest at any given time.

Meanwhile, on the mobile front, Huddle will enable group chatting among with your Google+ peers (similar to Beluga, which Facebook acquired in March) and Instant Uploads automatically uploads photos snapped with your mobile device to an online storage spot on Google+. You can watch 10 more videos explaining Google+ here.

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Source: http://www.techspot.com/news/44465-google-takes-aim-at-facebook-with-google.html

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Microsoft already working on Windows Phone updates Tango, Apollo

Microsoft has been showing off its next Windows Phone update, which is expected to begin rolling out this fall, and is codenamed Mango. At the same time though, the software giant is also working on the next Windows Phone updates, codenamed Tango and Apollo.

Compal Communications, which manufacturers devices for Acer and Nokia, recently signed a deal with Microsoft to build devices for Mango as well as the next-generation Tango update, according to DigiTimes. Last year, we heard of that the second major update to Windows Phone will be Apollo, due toward the end of 2012.

Of course, this can all change as we learn more about Tango and Apollo. After all, at some point Microsoft will have to release Windows Phone 8. It's very possible that one of these updates is actually Windows Phone 8, or an update to Windows Phone 8.

For now though, Windows Phone users should keep their eyes peeled for Windows Phone 7.5 (codenamed Mango). Check out our preview of the update from last week. We'll keep you posted on Tango and Apollo as we learn more.

It's generally accepted that Windows Phone is not selling well. AT&T Mobility CEO believes things will start to pick up with Mango and as the Windows Phone Marketplace gains more apps. Nokia CEO Stephen Elop meanwhile argues that Windows Phone scores better than Android and iPhone with consumers, but OEMs are doing their best work for Android. He believes that once Nokia starts doing its best work for Windows Phone, the platform will take off.

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Gaming 27 - The PlayStation Ryvita

Gaming 27 - The PlayStation Ryvita

Revealing Secrets with a Click

Individuals are growing conscious of the privacy risks that come with surfing the Web, but it turns out that businesses often overexpose themselves too. The problem often arises when workers visit websites for job-related reasons.

Say, for example, that a company is working on a new smart phone. Its engineers research other products and check out how competitors are marketing them. What they may not realize is that their visits show up in the log files of the competitors' websites, and some simple sleuthing can reveal who was visiting and what that visitor might have been up to. In particular, Web surfers reveal themselves through their IP addresses?unique identifiers that are tied to particular computers. IP addresses can be used to infer location. Often, it's also possible to discern who owns the address, particularly when that entity is a corporation.

"By watching the competitor's Web activity, you can time their development cycle," says Lance Cottrell, chief scientist and founder of Anonymizer, a company that helps businesses and individuals conceal private information when searching the Web. "The Internet just kind of feels anonymous, but it's really exactly the opposite. Every single thing you do on the Internet is tracked."

Jules Polonetsky, director of a think tank called the Future of Privacy Forum, agrees. "Treat it like you would if you were showing up at their plants," he says. Polonetsky jokes that if T-Mobile employees working on a new smart phone kept going into Sprint retail stores wearing uniforms and homing in on a particular device, no one would be at all surprised if Sprint made some intelligent guesses about T-Mobile's plans. Yet this is what companies do virtually when they research competitors carelessly and allow their IP addresses to show up in the competitors' logs. While "the risk isn't huge for most folks," Polonetsky says, businesses with special privacy concerns should be careful.

Cottrell has built a business out of those special situations. Although he can't reveal the identities of Anonymizer's clients, he cites stories of working with industries ranging from airlines to pharmaceuticals to security.

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